The knowledge workforce is changing: global economic factors, increasing professional specialization, and rapid technological advancements mean that more individuals than ever can be found working in independent, modular, and mobile arrangements. Little is known about professional information practices or actions outside of traditional, centralized offices; however, the dynamic, unconventional, and less stable mobile work context diverges substantially from this model, and presents significant challenges and opportunities for the accomplishing of work tasks. This article identifies 5 main information practices geared toward mobilizing work, based on in‐depth interviews with 31 mobile knowledge workers (MKWs). It then uses these 5 practices as starting points for beginning to delineate the context of mobile knowledge work. We find that the information practices and information contexts of MKWs are mutually constitutive: challenges and opportunities of their work arrangements are what enable the development of practices that continually (re)construct productive spatial, temporal, social, and material contexts for work. This article contributes to an empirical understanding of the information practices of an increasingly visible yet understudied population, and to a theoretical understanding of the contemporary mobile knowledge work information context.