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Moderate‐to‐high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years

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Clinical and Experimental Pharmacology and Physiology

Published online on


The present study aimed to investigate the relationship between normal serum concentrations of thyrotropin (TSH) and urinary incontinence (IU), urinary infections, and quality of life in old women. Euthyroid post‐menopausal women without sarcopenia, estrogen replacement, emotional illness, and/or cancer were enrolled as participants. Anthropometric indicators, serum glucose and estradiol, and thyroid profile were measured. Sociodemographic, clinical, physical activity, and quality of life (SF‐36) surveys were applied. One‐hour pad test and International Consultation on Incontinence Questionnaire Short Form (ICIQ‐SF) were used to determine UI. Urinalysis was also done. In agreement with results from the pad test (cut‐off point ≥1.4 g), the ICIQ‐SF reveled approximately 50% of incontinent women. A high percentage of women had moderate–high bacteriuria and urinary infections. Logistic regression analysis showed that age is a risk factor for both UI and urinary infection. Diabetes, number of pregnancies or childbirths, urinary infections, and bacteriuria did not influence the presence of UI. To allocate women into four groups according to their age (<65 or ≥65 years old) and TSH concentrations (0.3‐1.9 or 2‐10 μUI/mL), we found that moderate‐to‐high normal levels of TSH is a risk factor for UI and a worse quality of life in the oldest women. Our results highlight the profit of measuring TSH concentrations in post‐menopausal women.