Social relationships unfold face‐to‐face and across an increasingly diverse set of mobile, Internet‐based media. Research on these mixed‐media relationships (MMRs) offers a unifying focus for understanding of how media use reflects and drives social relationships. Impediments to research on mixed‐media interaction include an over‐reliance on research focused on a single medium, incomplete and conceptually problematic classifications of media, and limited theoretic approaches. An alternative approach to understand MMRs, grounded in the challenges of managing complex, recurring interpersonal demands, is proposed. These demands include social coordination, impression management, regulating closeness and distance, and managing arousal and anxiety. Implications of MMRs for mediatization and mass communication are briefly examined.