This study introduces the network weight matrix as a replacement for the spatial weight matrix to measure the spatial dependence between links of a network. This matrix stems from the concepts of betweenness centrality and vulnerability in network science. The elements of the matrix are a function not simply of proximity, but of network topology, network structure, and demand configuration. The network weight matrix has distinctive characteristics, which are capable of reflecting spatial dependence between traffic links: (1) elements are allowed to have negative and positive values capturing the competitive and complementary nature of links, (2) diagonal elements are not fixed to zero, which takes the self‐dependence of a link upon itself into consideration, and (3) elements not only reflect the spatial dependence based on the network structure, but they acknowledge the demand configuration as well. We verify the network weight matrix by modeling traffic flows in a 3 × 3 grid test network with 9 nodes and 24 directed links connecting 72 origin‐destination (OD) pairs. Models encompassing the network weight matrix outperform both models without spatial components and models with the spatial weight matrix. The network weight matrix represents a more accurate and defensible spatial dependency between traffic links, and offers the potential to augment traffic flow prediction.