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Extracellular vesicles as immune mediators in response to kidney injury

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Renal Physiology

Published online on

Abstract

Important progress has been made on the cytokine signalling in response to kidney injury in the past decade, especially cytokine signalling mediated by extracellular vesicles (EVs). For example, EVs released by injured renal tubular epithelial cells (TECs) can regulate inter-cellular communications and influence tissue recovery via both regulating the expression and transferring cytokines, growth factors, as well as other bioactive molecules at the site of injury. The effects of EVs on kidney tissue seem to vary depending on the sources of EVs; however, the literature data are often inconsistent. For example, EVs derived from mesenchymal stem cells (MSC-EVs) and endothelial progenitor cells (EPC-EVs) were shown to have both beneficial and harmful effects on injured renal tissue in rodents. Cautions are thus needed on the interpretation of these data as contradictory findings on EVs may not only be related to the origin of EVs, they can also be caused by the different methods used for EV isolation, and the physiological and pathological state of the tissues/cells under which they were obtained. Here, we review and discuss our current understanding related to the immunomodulatory function of EVs in renal tubular repair in the hope to encourage further investigation on mechanisms related to both the anti-inflammatory and the reparative roles of EVs, and to better define the therapeutic potential of EVs in renal diseases.