This essay is concerned with the epistemological complications of the interface between psychoanalysis and “scientific” disciplines and methodologies—in particular, with respect to theories of knowledge and conceptualizations of subjectivity appropriate to psychoanalysis. The author suggests that there is in such interface the potential for an untheorized scientism in empiricist prescriptions for the reform and rescue of psychoanalysis, and revisits the notion that subjectivity as conceived psychoanalytically, grounded in lived experience, is irreducible in ways that are unique and existentially abiding. The author explores the problem through the lens of philosophical hermeneutics and cautions against merging psychoanalysis, under the guise of a salutary pluralism, with disciplines guided by a systematized empiricism and its attendant epistemological commitments.