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Relationships between meconium concentrations of acute phase proteins

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Clinical and Experimental Pharmacology and Physiology

Published online on

Abstract

--- - |2 Abstract Meconium concentrations of naturally accumulated ceruloplasmin (CER), lactoferrin (LF), and neutrophil gelatinase–associated lipocalin (NGAL) and their relationships considered as a panel of acute phase proteins could be used for the assessment of fetal homeostasis. CER, LF and NGAL concentrations were measured using ELISA kits in meconium portions (n=80) collected from 19 healthy neonates. The coefficients of variation (CV) of the meconium LF (1.77) and NGAL (1.26) were about 2‐fold higher than that of CER (0.73) with significant (p<0.05) correlations between all three parameters. The LF to NGAL ratio (CV=0.67) correlated strongly with the CER concentrations (r=0.39, p<0.01). These correlations between CER, LF and NGAL concentrations suggest their combined involvement in the metabolic processes in the developing fetus. This article is protected by copyright. All rights reserved. - Clinical and Experimental Pharmacology and Physiology, Volume 0, Issue ja, -Not available-.