Association of the genetic polymorphisms in immunoinflammatory microRNAs with risk of ischemic stroke and subtypes in an Iranian population
Journal of Cellular Physiology
Published online on September 19, 2018
Abstract
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- "\nAbstract\nStroke is one of the most common type of cerebrovascular disease threatening
human health and life with high mortality, disability, and morbidity. Ischemic stroke
(IS) is determined to be a complex disease containing a group of heterogeneous disorders
with various environmental and genetic risk factors. This study evaluated the polymorphisms
of microRNAs involved in inflammatory routes leading to stroke in an Iranian population.
This study evaluated the associations of hsa‐mir‐608 C/G rs4919510, hsa‐mir‐499
A/G rs3746444, and hsa‐mir‐145 C/T rs190323149 polymorphisms in precursor miRNAs
with the risk of IS. These microRNA polymorphisms were analyzed in 470 patients
with IS and 489 control subjects. The TOAST criteria was applied for IS subtypes
classification. The frequency of the allele G of hsa‐mir‐499/rs3746444 A/G revealed
significant association with IS in comparison with controls (\np < 0.0001, OR = 1.838,
95% CI = 1.406–2.401). Increased IS risks were associated with hsa‐mir‐499/ rs3746444
A/G genotypes in diverse genetic model (homozygote comparison: \np = 0.004, OR = 2.136,
95% CI = 1.269–3.597; heterozygote comparison: \np = 0.029, OR = 1.373, 95% CI = 1.033–1.825).
Statistical analysis in IS subtypes showed that cardio‐embolic patients compared
with other subtypes (large artery atherosclerosis and lacunar) had higher frequency
of G allele (LAA vs. CEI, \np = 0.017; LAC vs. CEI, \np = 0.009), AG genotype (LAA
vs. CEI, \np = 0.016; LAC vs. CEI, \np = 0.013). Nevertheless, this study did not
find any association between the alleles and genotypes of mir‐608 C/G rs4919510
SNP and IS, respectively (\np > 0.05). The current investigation provided verification
that hsa‐mir‐499 rs3746444 A/G polymorphism may be associated with a significantly
increased risk of IS in an Iranian population.\n"
- Journal of Cellular Physiology, EarlyView.