A genetic variant in CDKN2A/2B locus was associated with poor prognosis in patients with esophageal squamous cell carcinoma
Journal of Cellular Physiology
Published online on September 21, 2018
Abstract
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- "\nAbstract\nEsophageal squamous cell carcinoma (ESCC) is among the leading causes
of cancer related death. Despite of extensive efforts in identifying valid cancer
prognostic biomarkers, only a very small number of markers have been identified.
Several genetic variants in the 9p21 region have been identified that are associated
with the risk of multiple cancers. Here, we explored the association of two genetic
variants in the 9p21 region, CDKN2A/B, rs10811661, and rs1333049 for the first time
in 273 subjects with, or without ESCC. We observed that the patients with ESCC had
a higher frequency of a TT genotype for rs10811661 than individuals in the control
group, and this polymorphism was also associated with tumor size. Moreover, a CC
genotype for the rs1333049 polymorphism was associated with a reduced overall survival
(OS) of patients with ESCC. In particular, patients with a CC (rs1333049) genotype
had a significantly shorter OS (CC genotype: 34.5 ± 8.9 months vs. CG+GG: 47.7 ± 5.9
months; \np value = 0.03). We have also shown the association of a novel genetic
variant in CDKN2B gene with clinical outcome of patients with ESCC. Further investigations
are warranted in a larger population to explore the value of emerging markers as
a risk stratification marker in ESCC."
- Journal of Cellular Physiology, EarlyView.