HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles
Journal of Cellular Physiology
Published online on September 24, 2018
Abstract
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- "\nAbstract\nHistone deacetylase 8 (HDAC8) is a class 1 histone deacetylase and
a member of the cohesin complex. HDAC8 is expressed in smooth muscles, but its expression
in skeletal muscle has not been described. We have shown for the first time that
HDAC8 is expressed in human and zebrafish skeletal muscles. Using RD/12 and RD/18
rhabdomyosarcoma cells with low and high differentiation potency, respectively,
we highlighted a specific correlation with \nHDAC8 expression and an advanced stage
of muscle differentiation. We inhibited HDAC8 activity through a specific PCI‐34051
inhibitor in murine C2C12 myoblasts and zebrafish embryos, and we observed skeletal
muscles differentiation impairment. We also found a positive regulation of the canonical
Wnt signaling by HDAC8 that might explain muscle differentiation defects. These
findings suggest a novel mechanism through which HDAC8 expression, in a specific
time window of skeletal muscle development, positively regulates canonical Wnt pathway
that is necessary for muscle differentiation."
- Journal of Cellular Physiology, EarlyView.