--- - |2+ Background Life satisfaction (LS) in children and adolescents is important because of its effects on their school performance and the future adulthood life. In this multicentric study, we examined some determinants of LS in the pediatric age group. Method This multicentric study was a part of the fourth national school‐based surveillance program in Iran (2011–2012). It was conducted among 14,880 children and adolescents, aged 6–18 years, living in 30 provinces in Iran. We used the questionnaire of the World Health Organization on Global School‐based Health Survey (WHO‐GSHS), which was translated to Persian and validated in Iranian children and adolescents. LS was defined by a single question: ‘Generally, which score between 0 (the worst) to 10 (the best) do you feel well describes your life at the moment?’ The score of six and above was considered as satisfied. Multivariate logistic regression analysis was conducted to investigate the determinants of LS. Results In total, 13,486 students completed the study (response rate 90.6%). Overall, 86.7%, 78.19%, and 71.44 of students were satisfied with their life in elementary, middle, and high schools. Students in middle school (OR 0.83; 95% CI 0.73, 0.96) and high schools (OR 0.63; 95% CI 0.54, 0.72) were less satisfied with their life. Students with moderate (OR 1.36; 95% CI 1.20, 1.54) and good (OR 1.66; 95% CI 1.44, 1.91) socioeconomic status were more satisfied than those with low status. Those who consulted with one (OR 1.56; 95% CI 1.34, 1.81) or both (OR 2.22; 95% CI 1.89, 2.60) of their parents were more satisfied with their life. Students who felt being accepted by their peers were 1.34 (95% CI 1.18, 1.52) times more satisfied with their life. Other associated variables were weekly (OR 1.3; 95% CI 1.12, 1.572) or daily (OR 1.6; 95% CI 01.12, 1.57) fruit consumption, moderate (OR 1.14; 95% CI 1.01, 1.29) and high (OR 1.1; 95% CI 1.02, 1.347) physical activity, good self‐rated health (OR 2.11; 95% CI 1.88, 2.37), and daily tooth brushing (OR 1.31; 95% CI 1.18, 1.46). Students with anxiety (OR 0.73; 95% CI 0.65, 0.82) and depression (OR 0.73; 95% CI 0.58, 0.74) were less satisfied with their life. Conclusion Some demographic and lifestyle factors, including higher socioeconomic status, consultation with parents, healthy dietary, and physical activity habits, were associated with higher LS in children and adolescents. Then, interventions that focus on improving lifestyle factors and parents’ support could increase LS among children and adolescents. - Child and Adolescent Mental Health, Volume 23, Issue 3, Page 228-234, September 2018.