--- - |2+ Background Routine outcome monitoring (ROM) may enhance individual treatment and is also advocated as a means to compare the outcome of different treatment programs or providers. There is debate on the optimal instruments to be used for these separate tasks. Methods Three sets with longitudinal data from ROM were analyzed with correlational analysis and repeated measures ANOVAs, allowing for a head‐to‐head comparison of measures regarding their sensitivity to detect change. The responsiveness of three disorder‐specific instruments, the Beck Depression Inventory, the Inventory of Depressive Symptoms, and the Mood and Anxiety Symptoms Questionnaire, was compared to three generic instruments, the Symptom Checklist (SCL‐90), the Outcome Questionnaire (OQ‐45), and the Brief Symptom Inventory, respectively. Results In two of the three datasets, disorder‐specific measures were more responsive compared to the total score on generic instruments. Subscale scores for depression embedded within generic instruments are second best and almost match disorder‐specific scales in responsiveness. No evidence of a desynchronous response on outcome measures was found. Limitations The present study compares measures head‐to‐had, and responsiveness is not assessed against an external criterion, such as clinical recovery. Discussion Disorder‐specific measures yield the most precise assessment for individual treatment and are recommended for clinical use. Generic measures may allow for comparisons across diagnostic groups and their embedded subscales approach the responsiveness of disorder‐specific measures. - Depression and Anxiety, EarlyView.