--- - |2 Functional analysis (FA) of problem behavior typically includes the contingent delivery of a single reinforcer following problem behavior. However, the FA literature also includes examples of analyses that have delivered multiple reinforcers, arranged multiple establishing operations in one or more test conditions, or both. These analyses have been successfully applied under heterogeneous conditions over several decades and with various synthesized establishing operations and reinforcers, but their qualitative details, outcomes, and contributions to the literature have never been described in a comprehensive manner. The purpose of the current review is to: (a) identify articles that have reported the use of synthesized FAs or treatments; (b) describe the nature and scope of synthesis as it has been applied in the FA literature; (c) analyze outcomes of synthesized FAs and treatments to determine general benefits and disadvantages of synthesis; and (d) offer recommendations for future areas of research. - Journal of Applied Behavior Analysis, Volume 51, Issue 4, Page 943-973, Fall 2018.