--- - |2 The high‐probability (high‐p) instructional sequence involves the delivery of a series of high‐probability instructions immediately before delivery of a low‐probability or target instruction. It has been shown to be efficacious for treating noncompliance among children and individuals with intellectual disabilities. Previous research (Esch & Fryling, ) has suggested that matching the topography of the response required to comply with high‐p instructions with the topography of the response required to comply with the low‐p instruction in the sequence may lead to greater increases in compliance with the low‐p instruction. In this study, we compared high‐p instructions that required both similar and dissimilar responses to two topographies of low‐p instructions (motor and vocal) among two young children. Results suggested that the topography of the response required by the high‐p instructions did not affect levels of compliance with low‐p instructions for either participant. Implications of these findings and directions for future research are discussed. - Journal of Applied Behavior Analysis, Volume 51, Issue 4, Page 866-878, Fall 2018.