--- - |2+ Abstract Objectives This study examined relations between comprehensive domains of psychosocial disability and mental disorders to determine (1) whether differential patterns of associations exist between psychosocial disability dimensions and commonly diagnosed mental disorders and (2) whether these relations differ between self‐reported and interviewer‐rated psychosocial disability domains. Method Self‐reported and interviewer‐rated psychosocial functioning measures and an interviewer‐rated diagnostic assessment tool were administered to 181 psychiatric outpatients. Results Internalizing disorders showed the strongest and most pervasive associations with psychosocial impairment across both self‐reported and interviewer‐rated measures, followed by thought disorder; externalizing showed the weakest associations. More specifically, logistic regression analyses indicated that lower well‐being factor score significantly increased the odds of distress‐disorder diagnoses, and poor basic functioning increased the odds of PTSD. Conclusions Results clearly showed differences in the magnitude of associations between three dimensions of psychosocial‐disability and commonly diagnosed disorders, and that these differences were similar regardless of rater type. - Journal of Clinical Psychology, EarlyView.