--- - |2+ Abstract Objective  Despite the ample literature on gender differences in anxiety and mood disorders, gender differences in social anxiety disorder (SAD) have received little empirical attention. The aim of the present study is to examine gender differences in 12‐months prevalence, patterns of comorbidity, clinical presentation, subjective distress and functional impairment, age of onset, and treatment seeking, and discuss their clinical implications. Method We used data from the National Comorbidity Survey‐Replication (NCS‐R; n = 652, 63.3% women) to examine gender differences. Results Main findings highlighted that compared with men, women are more likely to have SAD, to have a more severe clinical presentation of the disorder and to have greater subjective distress. Women are more likely than men to have comorbid specific phobia, generalized anxiety disorder and posttraumatic stress disorder, whereas men are more likely to have comorbid substance abuse disorders and conduct disorder. Conclusions Greater SAD prevalence and severity among women can have implications for assessment (e.g., potentially setting gender‐specific cutoffs) and treatment (e.g., guiding exposures) of SAD. - Journal of Clinical Psychology, EarlyView.