--- - |2 Children's perceptions of caregivers as a secure base have been linked with socioemotional outcomes, but little is known about connections to physical health. We examined whether secure base representations are associated with children's symptoms, family management strategies, and inflammatory processes in children with asthma. Participants included 308 children (ages 8–17) and one parent. Children completed a blood draw to measure asthma‐related immune functions and reported on perceptions of their mothers as a secure base and their asthma symptoms. Dyads completed interviews about asthma management. Analyses revealed that children's secure base perceptions were associated with better family asthma management and lower Type 2 T‐helper cell cytokine production. These findings suggest that secure base representations may be protective for children with asthma. - Child Development, EarlyView.