--- - |2 Using data from a cohort study of students at risk for high school dropout, we examined associations between violence exposure and past 30‐day alcohol and marijuana use. We used varying‐coefficient regression with person‐level fixed effects to estimate how those associations changed within‐person across ages approximately 14–23. Generally, violence perpetration was most strongly associated with substance use, within‐person. Substance use became increasingly associated with both observed violence and violence perpetration during early/middle adolescence; this increase continued longer into development (age 18+) for alcohol use. Across most of the age range studied here, violence victimization was minimally associated with within‐person changes in substance use. Results indicate age‐specific associations between violence exposure and alcohol and other drug use, which may be useful for informing prevention strategies. - Journal of Research on Adolescence, EarlyView.