--- - |2 Abstract Children from Latino migrant farmworker (LMFW) families are one of the most educationally disenfranchised and marginalized populations of students in the United States. These children face similar disadvantages to other low‐income immigrant families, but often experience unique contextual stressors due to high mobility that places them at high risk for mental health problems, risk‐taking behaviors, and poor academic engagement. Despite these high vulnerabilities few researchers have focused their efforts on LMFW children specifically, or addressed resilience factors in particular. Ego‐resiliency is an enduring psychological construct reflecting how individuals overcome day‐to‐day challenges. We used a convergent mixed method cross‐sectional design to examine the effects of LMFW children's (N = 66, ages 6–18, Mage = 12.79) depressive and conduct problems on their academic efficacy/mastery, and whether ego‐resiliency counteracted these relations. Ego‐resiliency was negatively associated with depression and conduct problems, and positively related to academic efficacy/mastery. Conduct problems were negatively related to academic efficacy/mastery, but depression was not. Ego‐resiliency also moderated the relation of depression to academic efficacy/mastery. Qualitative results provided a deeper explanation of contributing factors to LMFW children's adjustment, how adjustment problems affected their academic success, and the coping mechanisms and resilience factors used by LMFW children to overcome difficult experiences. - Social Development, EarlyView.