--- - |2 Abstract Pfattheicher and colleagues recently published an article entitled ‘Old Wine in New Bottles? The Case of Self‐compassion and Neuroticism’ that argues the negative items of the Self‐compassion Scale (SCS), which represent reduced uncompassionate self‐responding, are redundant with neuroticism (especially its depression and anxiety facets) and do not evidence incremental validity in predicting life satisfaction. Using potentially problematic methods to examine the factor structure of the SCS (higher‐order confirmatory factor analysis), they suggest a total self‐compassion score should not be used and negative items should be dropped. In Study 1, we present a reanalysis of their data using what we argue are more theoretically appropriate methods (bifactor exploratory structural equation modelling) that support use of a global self‐compassion factor (explaining 94% of item variance) over separate factors representing compassionate and reduced uncompassionate self‐responding. While self‐compassion evidenced a large correlation with neuroticism and depression and a small correlation with anxiety, it explained meaningful incremental validity in life satisfaction compared with neuroticism, depression, and anxiety. Findings were replicated in Study 2, which examined emotion regulation. Study 3 established the incremental validity of negative items with multiple well‐being outcomes. We conclude that although self‐compassion overlaps with neuroticism, the two constructs are distinct. © 2018 European Association of Personality Psychology - European Journal of Personality, Volume 32, Issue 4, Page 371-392, July/August 2018.