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Unfolding the pleiotropic facades of rosuvastatin in therapeutic intervention of myriads of neurodegenerative disorders

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Clinical and Experimental Pharmacology and Physiology

Published online on


--- - |2 Abstract Rosuvastatin, a 3‐hydroxy‐3‐methylglutaryl‐coenzyme (HMG‐CoA) reductase inhibitor, and one of the most popular antihyperlipidemic medications has been found to possess pharmacodynamic activities much different from its usual indication. Recent research studies have revealed the efficacy of rosuvastatin in attenuating neuroinflammation, reducing the progression of Alzheimer's disease, providing protection against cerebral ischemia and spinal cord injury as well as ameliorating epilepsy. Mechanisms behind the neuroprotective potential of rosuvastatin can be attributed to its pleiotropic effects, independent of its ability to inhibit HMG‐CoA reductase. These processes include modulation of several cellular pathways, isoprenylation, effects on oxidative stress, nitrosative levels, inflammation, and immune response. With this review, we aim to assimilate and summarize recent findings on the pharmacological actions of rosuvastatin in attenuating neurological disorders in order to give way for future research in this space. This article is protected by copyright. All rights reserved. - Clinical and Experimental Pharmacology and Physiology, Volume 0, Issue ja, -Not available-.