--- - |2 Abstract A novel epigenetic regulator, Jarid1b (KDM5B), that contributes to increasing vascular soluble epoxide hydrolase (sEH) protein expression and impairing endothelial function was identified by Vasconez et al. in this edition of Acta Physiologica. Elevated angiotensin II levels contribute to several cardiovascular diseases and endothelial dysfunction in hypertension. Endothelial dysfunction in angiotensin II dependent hypertension is partly due to increased sEH activity. This article is protected by copyright. All rights reserved. - Acta Physiologica, Volume 0, Issue ja, -Not available-.