EA15, MIR22, LINC00472 as diagnostic markers for diabetic kidney disease
Journal of Cellular Physiology
Published online on October 14, 2018
Abstract
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- "\nAbstract\nThis study aimed to investigate the molecular mechanisms of diabetic
kidney disease (DKD) and to explore new potential therapeutic strategies and biomarkers
for DKD. First we analyzed the differentially expressed changes between patients
with DKD and the control group using the chip data in Gene Expression Omnibus (GEO)
database. Then the gene chip was subjected to be annotated again, so as to screen
long noncoding RNAs (lncRNAs) and study expression differences of these lncRNAs
in DKD and controlled samples. At last, the function of the differential lncRNAs
was analyzed. A total of 252 lncRNAs were identified, and 14 were differentially
expressed. In addition, there were 1,629 differentially expressed messenger RNAs
(mRNAs) genes, and proliferation and apoptosis adapter protein 15 (PEA15), \nMIR22,
and long intergenic nonprotein coding RNA 472 (\nLINC00472) were significantly differentially
expressed in DKD samples. Through functional analysis of the encoding genes coexpressed
by the three lncRNAs, we found these genes were mainly enriched in type 1 diabetes
and autoimmune thyroid disease pathways, whereas in Gene Ontology (GO) function
classification, they were also mainly enriched in the immune response, type I interferon
signaling pathways, interferon‐γ mediated signaling pathways, and so forth. To summary,
we identified \nEA15, \nMIR22, and \nLINC00472 may serve as the potential diagnostic
markers of DKD."
- Journal of Cellular Physiology, EarlyView.