MetaTOC stay on top of your field, easily

Zic1 mRNA is transiently upregulated in subcutaneous fat of acutely cold‐exposed mice

, , , , , ,

Journal of Cellular Physiology

Published online on


--- - "\nAbstract\nIn the mammalian adipose organ cold exposure not only activates typical brown adipose tissue, but also induces browning, that is the formation of thermogenic multilocular adipocytes in white, or predominantly white, adipose depots such as subcutaneous fat. Unlike typical brown adipocytes, newly formed thermogenic adipocytes have been reported not to express the gene zinc finger of the cerebellum 1 (Zic1). Here, a time course approach enabled us to document a significant increase in \nZic1 messenger RNA in inguinal subcutaneous fat from acutely (24 hr) cold‐exposed mice, which was paralleled by an increase in multilocular and paucilocular uncoupling protein 1‐positive adipocytes and in parenchymal noradrenergic innervation. This transient, depot‐specific molecular signature was associated not to \nZic1 promoter demethylation, but to chromatin remodeling through an H3K9me3 histone modification. These findings challenge the notion that \nZic1 is exclusively expressed by typical brown adipocytes and suggest its involvement in brown adipocyte precursor differentiation and/or white‐to‐brown adipocyte transdifferentiation." - Journal of Cellular Physiology, EarlyView.