MetaTOC stay on top of your field, easily

The role of ErbB3 binding protein 1 in cancer: Friend or foe?

, , , , , ,

Journal of Cellular Physiology

Published online on

Abstract

--- - |2- ErbB3, a member of the epidermal growth factor receptor family, reportedly plays an essential role in the regulation of cancer progression and therapeutic resistance. Numerous studies have indicated that ErbB3 binding protein 1 (Ebp1), a binding partner for ErbB3, plays an important regulatory role in the expression and function of ErbB3, but there is no agreement as to whether Ebp1 also has an ErbB3‐independent function in cancer and how it might contribute to tumorigenesis. In this review, we will discuss the different functions of the two Ebp1 isoforms, p48 and p42, that may be responsible for the potentially dual role of Ebp1 in cancer growth. - Journal of Cellular Physiology, Volume 233, Issue 12, Page 9110-9120, December 2018.