--- - |2- In this review, we examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3 F442A and also concentrated our attention on research published during the last few years, emphasizing data described to regulate adipose differentiation, outside of those that are part of the canonical adipogenic transcriptional cascade. Adipose cells store lipids in the cytoplasm and signal systemically through secretion of adipokines and other molecules that regulate body energy metabolism. Differentiation of fat cells and its regulation has been the focus of extensive research since the early 1970s. In this review, we had attempted to examine the research bearing on the control of adipose cell differentiation, some of it dating back to the early days when Howard Green and his group described the preadipocyte cell lines 3T3‐L1 and 3T3‐F442A during 1974–1975. We also concentrated our attention on research published during the last few years, emphasizing data described on transcription factors that regulate adipose differentiation, outside of those that were reported earlier as part of the canonical adipogenic transcriptional cascade, which has been the subject of ample reviews by several groups of researchers. We focused on the studies carried out with the two preadipocyte cell culture models, the 3T3‐L1 and 3T3‐F442A cells that have provided essential data on adipose biology. - 'Journal of Cellular Physiology, Volume 234, Issue 2, Page 1111-1129, February 2019. '