--- - |2- microRNAs have a very crucial role in tumorgenesis and prevention of cancer, which play a significant role in influencing various factors through different signaling pathways. microRNAs can act as tumor suppressors and oncomirs in this cancer through phosphoinositide 3‐kinase/AKT signaling pathway. Abstract In recent decades, cancer has been one of the most important concerns of the human community, which affects human life from many different ways, such as breast, lung, colorectal, prostate, and other cancers. Colorectal cancer is one of the most commonly diagnosed cancers in the world that has recently been introduced as the third leading cause of cancer deaths in the world. microRNAs have a very crucial role in tumorgenesis and prevention of cancer, which plays a significant role with influencing various factors through different signaling pathways. Phosphoinositide 3 (PI3)‐kinase/AKT is one of the most important signaling pathways involved in the control and growth of tumor in colorectal cancer, through important proteins of this pathway, such as PTEN and AKT, that they can perform specific influence on this process. Our effort in this study is to collect microRNAs that act as tumor suppressors and oncomirs in this cancer through PI3‐kinase/AKT signaling pathway. - 'Journal of Cellular Physiology, EarlyView. '