--- - |2- Stem cell therapy has been recommended as a probable therapeutic approach for patients with osteoporosis. Even though the concept of stem cell‐based therapy for osteoporosis has suggested substantial attention over the years, no clinical trial has been published in humans. The cell studies on the basis of osteoporosis are primarily attentive on osteoclastic activity and bone resorption procedures; at that point on osteoblastogenesis, and in recent times on the differentiation probable of mesenchymal stem cells. In this review, we have summarized the therapeutic role of stem cell‐based strategy in osteoporosis. Abstract Osteoporosis is a systemic skeletal disease associated with reduced bone strong point that results in raised fracture risk, with decreased bone strength, leading to reduced bone mineral density and poor bone quality. It is the most common in older females but some men are also at high risk. Although considered as a predictable result of aging, it is can be avoidable and treatable. The existing treatment of osteoporosis mainly contains antiresorptive and anabolic agents. In spite of these improvements, concerns around unusual side‐effects of antiresorptive drugs, and the lack of perfect confirmation in maintenance of their long‐standing effectiveness is bring about many patients not receiving these drugs. Over the years, the stem cell‐based therapy has attained substantial clinical consideration because of its potential to treat numerous diseases. The stem cell therapy has been recommended as a probable therapeutic approach for patients with osteoporosis. Even though the concept of stem cell‐based therapy for osteoporosis has caught substantial attention, no clinical trial has been published on humans. The cell studies based on osteoporosis are primarily focused on osteoclastic activity and bone resorption procedures. Earlier, it was on osteoblastogenesis and in recent times, on the differentiation probable of mesenchymal stem cells. In this review, we have summarized the therapeutic role of stem cell‐based strategy in osteoporosis. - 'Journal of Cellular Physiology, EarlyView. '