Immunoresolvents in asthma and allergic diseases: Review and update
Journal of Cellular Physiology
Published online on November 29, 2018
Abstract
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Asthma and allergic diseases are inflammatory conditions developed by excessive reaction of the immune system against normally harmless environmental substances. Essential fatty‐acids‐derived immunoresolvents, namely, lipoxins, resolvins, protectins, and maresins are anti‐inflammatory compounds that are believed to have protective and beneficial effects in inflammatory disorders, including asthma and allergies.
Abstract
Asthma and allergic diseases are inflammatory conditions developed by excessive reaction of the immune system against normally harmless environmental substances. Although acute inflammation is necessary to eradicate the damaging agents, shifting to chronic inflammation can be potentially detrimental. Essential fatty‐acids‐derived immunoresolvents, namely, lipoxins, resolvins, protectins, and maresins, are anti‐inflammatory compounds that are believed to have protective and beneficial effects in inflammatory disorders, including asthma and allergies. Accordingly, impaired biosynthesis and defective production of immunoresolvents could be involved in the development of chronic inflammation. In this review, recent evidence on the anti‐inflam]matory effects of immunoresolvents, their enzymatic biosynthesis routes, as well as their receptors are discussed.
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