Sexual minority youth are known to face increased risk of poor school performance; however, little research has focused on the educational experiences of multiethnic sexual minority youth (MSMY) in particular. Using venue-based sampling approaches, this study surveyed 255 MSMY at 15 urban high schools. The majority of participants identified as female (65%), Latina (58%), and bisexual (41%), with a mean age of 16. The use of structural equation modeling techniques found that 23% of the variance of school performance was explained by the multivariate model. Examination of the model path coefficients revealed that experiences of perceived discrimination had a powerfully negative influence on the school performance of MSMY. Whereas increased family support was associated with better school performance, neither peer nor school support had similar impact. In addition, levels of support did not significantly moderate the effect of perceived discrimination on MSMY.