Foundational research on the link between neighborhood accessibility and burglary has consistently shown a positive association. However, recent research has found that less accessible neighborhoods have higher burglary rates. Geographically referenced data from 401 neighborhoods in Jacksonville, Florida, are used to determine whether these inconsistencies can be explained by a conditioning effect of neighborhood social-structural context. Results from spatially lagged regression models indicate that neighborhood accessibility fails to have a direct effect on burglary rates after social-structural variables are controlled; rather, the effect of neighborhood accessibility on burglary rates is conditioned by the level of concentrated disadvantage of the neighborhood. Two potential explanations for the empirical findings are offered, and implications of the results for "designing out" crime are discussed.