In this article, the effect of the deformed interface on the hydro-viscous drive characteristics was investigated through a three-dimensional fluid simulation and experiments. The main parameters such as pressure field, velocity field, and torque transferred by the oil film were simulated in FLUENT software in the light of the principle of the computational fluid dynamics. The results found that the dynamic pressure and velocity of the oil film goes up gradually along the radial direction, and the dynamic pressure at zone with groove is much higher than that without groove due to the hydrodynamic effect. After the interface deforming, the dynamic pressure decreases; while the torque transferred by the oil film increases slightly. Furthermore, a special hydro-viscous drive test-bed was developed to verify the correctness and validity of the theoretical results.