This paper deals with an experimental investigation to measure the frictional pressure drops for two-phase flow boiling in a micro-channel with a hydraulic diameter of 500 µm. First, the experimental study is performed under the test conditions: heat fluxes ranging from 100 to 400 kW/m², vapor qualities from 0 to 0.2, and mass fluxes of 200, 400 and 600 kg/m²s. Then, the frictional pressure drop during flow boiling is estimated using two models: the homogeneous model and the separated flow model. The experimental results show that the two-phase multiplier decreases with the increase of mass flux. In addition, the measured pressure drops are compared with those from a few correlation models available for macro-scales and mini/micro-scales. Finally, the present paper proposes a new correlation for two-phase frictional pressure drops in mini/micro-scales. This correlation model is developed based on the Chisholm constant C as a function of two-phase Reynolds and Weber numbers. It is found that the new correlation satisfactorily predicts the experimental data within mean absolute error (MAE) of 3.9%.