Vibration analysis of axially moving functionally graded plates with internal line supports and temperature-dependent properties is investigated using harmonic differential quadrature method. The plate is subjected to static in-plane forces while out-of-plane loading is dynamic. Stability of an axially moving plate, traveling at a constant velocity between different supports and experiencing small transverse vibrations are considered. The series of internal rigid line supports parallel to the plate edges are considered together with various arbitrary combinations of boundary conditions. Material properties of the plate are assumed temperature-dependent which is a non-linear function of temperature and differ continuously through thickness according to a power-law distribution of the volume fractions of the plate constituents. Two types of micromechanical models, namely, the Voigt and Mori–Tanaka models are considered. Based on the classical plate theory, the governing equations are obtained for functionally graded plate using the Hamilton’s principle. In the frame of a general dynamic analysis, it is shown that the onset of instability takes place in the form of divergence. The plate may experience divergence or flutter instability at a super critical velocity. Results for dynamic analysis of isotropic and laminated plates are validated with available data in the existing literature, which show excellent agreement. Furthermore, some new results are presented for vibration analysis of functionally graded material plates to study effects of the location of line supports, material properties, volume fraction, temperature, loading, aspect ratio and speed.