In a sample of 346 college students, we compared students of different academic major areas in their personality characteristics, mental abilities, and vocational interests, and we examined the congruence between vocational interests and academic major as a predictor of academic outcomes (grade point average, satisfaction, and change of major). Results were mainly consistent with predicted differences between the four academic major groups (arts/humanities, business, science, and helping/child related), and several of the observed differences were moderately large. However, congruence between interests and major was unrelated to academic outcomes.