In this study, the authors focused on the context of physical disabilities (i.e., one’s age when a disability manifests and the severity with which it impacts major life activities) to better understand how disabilities influence vocational self-efficacies. Consistent with Social Cognitive Career Theory, age of onset moderated the relationship between disability severity and self-efficacies in the Realistic, Artistic, Social, and Conventional vocational domains. Specifically, disability severity had a strong, negative impact on self-efficacies for people who became physically disabled later in life. In contrast, the relationship between disability severity and self-efficacy was nonsignificant for people who became disabled in early childhood. These findings held across Holland’s Realistic, Investigative, Artistic, Social, Enterprising, and Conventional domains when controlling for a variety of other person inputs and domain-specific learning experiences.