The current study examines the role of meaning in life with respect to career indecision and state anxiety in a sample of 229 university students. This article seeks to build upon the career indecision literature by examining the role of meaning in life. An existential model of career indecision was applied in order to provide a theoretical framework for the relationship between career indecision and anxiety. Measures include the Career Decision Scale (Osipow, Carney, Winer, Yanico, & Koschier, 1976), the Meaning in Life Questionnaire (Steger, Frazier, Oishi, & Kaler, 2006), and the State-Trait Inventory for Cognitive and Somatic Anxiety (Ree, MacLeod, French, & Locke, 2000). Presence of meaning in life mediated the relationships between career indecision and anxiety. However, the results did not support the hypothesis that the search for meaning in life moderates the relationship between career indecision and anxiety. Future research and practical implications are also discussed.