The present study examined the role of goals in the relation between calling and life satisfaction in a diverse, adult sample. Building off the self-concordance model of goal progress, the current study explored whether career goal self-efficacy (CGSE) mediated the relation between calling and life satisfaction and whether this mediation was moderated by intrinsic, extrinsic, self-transcendence, or physical self goal aspirations. We found CGSE to partially mediate the relation between calling and life satisfaction. Additionally, self-transcendence goals and physical self goals moderated this mediation such that, for people high in calling, the mediation only existed for those with high self-transcendence goals or low physical self goals. These results suggest that people with callings may need to have self-transcendence goals and avoid physical self goals in order for the confidence in their ability to achieve career goals to mediate the relation between their sense of calling and life satisfaction. Limitations and implications for future research are discussed.