Defining city-region boundaries for governance or policy requires robust data analysis reflecting a conceptualisation of city-regions. Geddes introduced the concept to England and both fundamental and contingent features he identified remain valid. Subsequent work has not clarified issues raised by the contingent features and one of these—whether or not cities dominate the region definitions—here structures the review of city-region definition methods. Following a historical review of the failure of proposals for English city-region governance geography—which ascribes a key role in those failures to institutional inertia fuelled by rural interests—a review of the ‘city-centric’ methods which exacerbate rural opposition shows they fail to meet essential requirements. By contrast a ‘regions first’ approach to city-region definition is shown capable of implementing all the fundamental features of the concept, including the analysis of flows over and above those of commuting.