This paper focuses on the social implications of long-distance commuting on commuters and their spouses in Sweden. In a nation-wide study, the extent to which long-distance commuting increases the odds that couples will separate is investigated through event history analysis. Discrete-time logistic regression models were employed with longitudinal data on Swedish couples in 2000 to explore the odds of separation following long-distance commuting during 1995 to 2005. As expected, the results show that separation rates are higher among long-distance commuting couples compared with non-commuting couples. More complex results show that for men the odds of separating are highest if the commuting is on a temporary basis, and that women’s odds decrease when they continue commuting for a longer time-period. The long-distance commuting effect on relationships also varies depending on residential context.