This study examined the reciprocal relationship between Latinas’ leisure-time physical activity and neighborhood cohesion following the implementation of a 6-month promotora-delivered pilot intervention. A one-group study design was used to promote leisure-time physical activity and build neighborhood cohesion among 143 churchgoing Latinas in San Diego, California. Using a three-wave autoregressive cross-lagged panel model, leisure-time physical activity and neighborhood cohesion (assessed at baseline, 3 and 6 months) were analyzed. Leisure-time physical activity and neighborhood cohesion increased across time. Neighborhood cohesion at 3 months predicted leisure-time physical activity at 6 months. A promotora model in the context of a faith-based setting may be appropriate to promote Latinas’ leisure-time physical activity and make socioenvironmental improvements.