There is currently widespread interest in gender-responsive programming within the juvenile justice system. The research literature currently provides critical information about the needs of girls and pathways into the justice system through epidemiology or program evaluation studies; however, the experience of practitioners implementing reforms is less represented. This perspective is essential given the nascent stage of research on gender-specific best practices and the widespread adoption of gender-specific principles. In this article, the authors review the policy and research literature relevant to the gender-responsive movement and present the results of their multistate study of how principles are being translated into practice, including how reforms are being initiated and sustained. They discuss these findings in light of their implications for practice and research.