Objective Although the survival outcomes among women diagnosed with endometrial cancer are very favorable, little is known about the long‐term impact of their cancer experience. This study identifies the extent of positive and negative impacts of cancer and factors associated with this, amongst long‐term survivors of endometrial cancer. Methods Australian women diagnosed with endometrial cancer (N = 632) were sent questionnaires at the time of diagnosis and 3–5 years later. Hierarchical multiple regression models were used to examine whether a range of variables at diagnosis/treatment predicted subsequent scores on the Impact of Cancer Scale, which examines positive (e.g. health awareness) and negative (e.g. appearance concerns) impacts amongst cancer survivors. Results Overall, women had a higher mean score for the positive than negative impact scales (M = 3.5 versus M = 2.5, respectively). An intermediate grade of endometrial cancer, a prior diagnosis of cancer and lower levels of education were significant, but weak, predictors of higher scores on the positive impact scale. Higher scores on the negative impact scale were predicted by a higher grade of cancer, poor physical and mental health, a younger age, being single or having lower levels of education. Conclusions The study demonstrates that factors that predict positive impact in cancer survivors differ to those that predict negative impact, suggesting that interventions to optimize cancer survivors' quality of life will need to be multi‐dimensional, and this supports the need for tailored intervention. Copyright © 2012 John Wiley & Sons, Ltd.