This study examined whether engagement in fat talk would moderate the association between weight status (body mass index) and depression between female friends. Individuals’ body mass index was significantly related to their own (actor effect) and friend’s (partner effect) depression. For low-fat-talk friends, higher actor’s body mass index was associated with higher actor’s depression, but not for high-fat-talk friends. For high-fat-talk friends, higher actor’s body mass index was associated with higher partner’s depression, but not for low-fat-talk friends. Theoretical and practical implications are discussed.