Metaphors are powerful tools for sensemaking, sensegiving, and theory development, but they are often concealed in academic writing. This paper uncovers two metaphors underlying entrepreneurship discourse and research—elixir and mutagen. The elixir metaphor is uncovered by examining critiques of entrepreneurship research, and serves as a compact description of problematic aspects entrepreneurship scholars should be mindful of. The mutagen metaphor is uncovered by examining evolutionary frameworks, focusing on the role entrepreneurship plays in them. The paper illustrates how the mutagen metaphor can be used to reframe entrepreneurship, and uses the metaphors to interest, inform, and provoke.