How do African agricultural livelihoods change under stressful conditions? How do market and agricultural policies and development interventions impact on both agricultural and social change, and consequently on food self‐sufficiency? Which long‐term factors can contribute to ‘depeasantization’? Is the ‘New Green Revolution’ the best and only solution for African food insecurity? These are the main questions this paper sets out to address, using southern Guinea‐Bissau as a case study. On the basis of long‐term ethnographic fieldwork, we look at farmers' responses to external and internal pressures, and analyse how ‘depeasantization’ progresses and livelihoods have been losing their resilience. Chances to reverse this trend, although difficult to implement, may still be feasible.