This article analyses the effect of competition from low‐wage countries on domestic activity, using data on 230 Italian manufacturing sectors between 1995 and 2007. It finds that low‐wage import penetration is negatively related to employment and other measures of activity. The effect is significantly smaller in more skill, capital and R&D‐intensive sectors and in more vertically differentiated sectors. There is also evidence of significant effects of low‐wage competition through inter‐industry linkages: employment is negatively related to low‐wage import penetration in downstream sectors but positively related to low‐wage import penetration in upstream sectors.