Most of the literature on innovation management highlights the fundamental role played by people in the innovation process and the need to fully develop the creative and innovative potential of organizations' members. This article offers the result of extensive research carried out among some of the most innovative companies in the Basque Country, a highly innovative region located in the north of Spain. It draws interesting conclusions about how these innovative companies combine strong leadership, human resource practices, and an organizational culture that enhances innovation capabilities among the company's employees. More specifically, it answers questions such as the following: Are human resources policies, leadership, and innovation culture implemented equally in Basque innovative companies? Do companies make the same effort in deploying these elements or routines and practices related to them? Can we see a pattern in the use of these elements among innovative firms? © 2012 Wiley Periodicals, Inc.