This study explored the nature of interactions between adolescent males with ADHD and their mothers, and the effects of methylphenidate (MPH) on an analogue parent–teen interaction task. Twenty-five adolescent males with ADHD (M = 13.6 years) and their mothers and 14 non-ADHD adolescent males (M = 13.4 years) and their mothers completed ratings of perceived dyadic conflict. Behavioral observations of dyads during 10-min conflict-resolution tasks were also collected. The ADHD dyads completed these tasks twice, with adolescents receiving either 0.3 mg/kg MPH or placebo. Videotaped sessions were coded using the Parent–Adolescent Interaction Rating Scale. Following the conflict-resolution task, participants rated their perceived conflict and affect during the interaction. Findings indicated higher conflict in the ADHD dyads, and minimal MPH effects on parent–teen interactions during the analogue task. Results suggest that stimulant medication does not produce meaningful acute effects on parent–teen interactions. (J. of Att. Dis. 2013; XX(X) 1-XX)