The focus of this article is US military research in Greenland and its role in Danish‐American political relations in the early Cold War period 1945–1968. This was a period of intense US research activity that aimed to overcome the hostile Greenlandic environment and harness it for military purposes. In the US‐Danish defense agreement on Greenland of 1951 the USA got a free hand to develop three so‐called defense areas for military purposes, while it had to seek Danish permission for research and other activities outside these areas. The two partners had differing, but mainly compatible, interests in this process. The US interest was freedom to do research on the gigantic Greenland Icecap, while the Danish authorities emphasized the protection of its sovereignty over Greenland. The article follows the US research programs in the 1950s and 1960s and Danish responses in some detail, including the intriguing and still mysterious Camp Century project and its relationship with the US Army's Iceworm plan to deploy strategic missiles beneath the surface of the Greenland Icecap.